Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data
نویسندگان
چکیده
منابع مشابه
Expression of glutathione, glutathione peroxidase and glutathione S-transferase pi in canine mammary tumors
BACKGROUND Glutathione (GSH) is one of the most important agents of the antioxidant defense system of the cell because, in conjunction with the enzymes glutathione peroxidase (GSH-Px) and glutathione S transferase pi (GSTpi), it plays a central role in the detoxification and biotransformation of chemotherapeutic drugs. This study evaluated the expression of GSH and the GSH-Px and GSTpi enzymes ...
متن کاملReversible Conjugation of Ethacrynic Acid with Glutathione and Human Glutathione S-Transferase PI-1
The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an a,~-unsaturated ketone, with glutathione and glutathione S-transferase PI-1 (GST PI-I) has been studied. When the glutathione conjugate of EA was incubated with a 5-fold molar excess of Nacetyi-L-cysteine or GST PI-I, a time-dependent transfer of EA to N-acetyI-L-cysteine or GST PI-1 was observed. With i...
متن کاملReversible Conjugation of Ethacrynic Acid with Glutathione and Human Glutathione S-Transferase PI-1
The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an a,~-unsaturated ketone, with glutathione and glutathione S-transferase PI-1 (GST PI-I) has been studied. When the glutathione conjugate of EA was incubated with a 5-fold molar excess of Nacetyi-L-cysteine or GST PI-I, a time-dependent transfer of EA to N-acetyI-L-cysteine or GST PI-1 was observed. With i...
متن کاملReversible Conjugation of Ethacrynic Acid with Glutathione and Human Glutathione S-Transferase PI-1
The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an a,~-unsaturated ketone, with glutathione and glutathione S-transferase PI-1 (GST PI-I) has been studied. When the glutathione conjugate of EA was incubated with a 5-fold molar excess of Nacetyi-L-cysteine or GST PI-I, a time-dependent transfer of EA to N-acetyI-L-cysteine or GST PI-1 was observed. With i...
متن کاملReversible Conjugation of Ethacrynic Acid with Glutathione and Human Glutathione S-Transferase PI-1
The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an a,~-unsaturated ketone, with glutathione and glutathione S-transferase PI-1 (GST PI-I) has been studied. When the glutathione conjugate of EA was incubated with a 5-fold molar excess of Nacetyi-L-cysteine or GST PI-I, a time-dependent transfer of EA to N-acetyI-L-cysteine or GST PI-1 was observed. With i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1990
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1990.262